Trusted Genomics Platforms. Certified Expertise. Proven Quality.
As a recognized partner for 10x Genomics, Illumina, Olink, PacBio, and Twist Bioscience, Signios Bio delivers proven excellence in sequencing and data analysis.
Our certified network guarantees precision, reliability, and end-to-end quality across all genomic applications.
10x Genomics
Signios Bio offers comprehensive single-cell and spatial multi-omics solutions powered by 10x Genomics technology, enabling deep biological insights across diverse research applications:
- Gene Expression (3′ GEX): Quantify transcriptional profiles across thousands of cells for precise cell-type identification and transcriptomic studies.
- Immune Profiling: Map BCR and TCR repertoires to uncover adaptive immune responses in immunology, vaccine, and autoimmune research.
- Multi-Omics (ATAC + GEX): Integrate chromatin accessibility and gene expression at single-cell resolution to study epigenetic regulation and disease mechanisms.
- CITE-Seq & Cell Hashing: Combine protein marker and RNA expression data for advanced cell characterization and sample multiplexing.
- Single-Nuclei Sequencing: Analyze nuclei from frozen or archival tissues—ideal for neurological and other complex tissue studies.
- Visium (Spatial Transcriptomics): Perform whole-transcriptome spatial profiling on FFPE or fresh-frozen tissues using high-density barcoded slides, preserving tissue architecture for unbiased discovery of spatial gene expression patterns.
- Xenium (In Situ Spatial Transcriptomics): Visualize and quantify thousands of transcripts directly in tissue sections with sub-cellular resolution, combining spatial context with high-plex targeted sensitivity for precise cellular mapping.
Pacific Biosciences
Signios Bio provides advanced long-read sequencing solutions using PacBio HiFi technology, delivering high-accuracy, publication-ready genomic data for academic and biotechnology applications. Our long-read platform enables comprehensive insights across human, plant, microbial, and animal genomes.
- De Novo Genome Assembly & Annotation:
Generate complete, contiguous, and accurate genome assemblies with detailed gene and isoform annotations. Ideal for species with complex or polyploid genomes, overcoming limitations of short-read sequencing. - Comprehensive Human Variant Detection:
Identify structural variants (SVs), SNVs, and Indels with haplotype phasing for unmatched accuracy. HiFi sequencing resolves large or complex variants often missed by short-read platforms.
Illumina
Signios Bio offers high-throughput, cost-effective sequencing powered by Illumina platforms, delivering accurate data for diverse applications in human, plant, microbial, and animal genomics.
- Premade Library Sequencing:
Submit ready-to-run Illumina libraries (WGS, WES, RNA-seq, amplicon, bisulfite, TCR/BCR) for rapid, high-quality FASTQ output or complete bioinformatics support. - RNA Sequencing:
Comprehensive transcriptomic solutions for mRNA, total RNA, and low-input or FFPE samples — with QC, alignment, and differential expression analysis. - Whole-Genome Sequencing (WGS):
High-coverage, cost-efficient sequencing using NovaSeq X+, ideal for population studies and genome-wide variant discovery. - Whole-Exome Sequencing (WES):
Human and mouse exome capture using Agilent or Twist workflows with full variant calling, annotation, and CNV analysis.
Olink
Signios Bio provides high-throughput, NGS-based proteomics using Olink Reveal, enabling precise quantification of 1,000+ proteins from as little as 4 µL of plasma, serum, or CSF.
- Comprehensive biomarker profiling: Explore key pathways in inflammation, immunity, and signaling.
- Low input, scalable throughput: Ideal for large-cohort and multi-omics studies.
- Integrated workflow: End-to-end support from Olink assay setup to Illumina sequencing and bioinformatics via Olink Insight.
- Fast turnaround: Results typically delivered within 4 weeks.
Twist Bioscience
Signios Bio offers advanced NGS library prep solutions using Twist Bioscience’s technology for RNA, exome, and whole genome sequencing. These kits deliver exceptional coverage uniformity, specificity, and sensitivity for both research and clinical applications.
- Targeted Sequencing: Customize panels or use pre-designed ones to enrich specific genomic regions with high precision and minimal off-target reads. Ideal for oncology, inherited disease, and rare variant detection.
- Whole Exome Sequencing (WES): Achieve high, uniform coverage of coding regions for comprehensive variant discovery. Optimized for speed and performance across sample types.
- Whole Genome Sequencing (WGS): Scalable solutions for full-genome analysis with consistent performance across GC-rich and challenging regions.
- RNA Sequencing: Efficient, strand-specific transcriptome profiling for coding and non-coding RNAs, with low input requirements and robust detection of differentially expressed genes.