Epigenomic Sequencing Services
Advanced NGS and bioinformatics delivering reproducible, publication-ready epigenomic data.
Epigenomic Sequencing Services
Signios Bio provides a complete portfolio of epigenomic sequencing services, supporting discovery across chromatin accessibility, histone modifications, and DNA methylation. Our workflows include bulk and single-cell ATAC-Seq, CUT&RUN, ChIP-Seq, and methylome profiling, all powered by advanced bioinformatics.
As a trusted NGS provider based in California, we deliver high-quality, publication-ready data with fast turnaround and flexible input options. Whether you’re mapping chromatin states, profiling transcription factor binding, or integrating methylation data, Signios helps you generate reproducible insights for your epigenetics research.
Get detailed workflows, sample requirements, and example data outputs.
Our Epigenomic Sequencing Portfolio
Signios Bio provides a comprehensive suite of epigenetic sequencing assays to characterize chromatin accessibility, transcription factor binding, histone modifications, and DNA methylation.
Workflow
Key Applications
Typical Input Requirements
Workflow
Bulk ATAC-Seq
Key Applications
Chromatin accessibility mapping, nucleosome positioning
Typical Input Requirements
≥100k cells or 20–50 mg tissue
Workflow
Single-Cell ATAC-Seq
Key Applications
Cell-level chromatin profiling, heterogeneity studies
Typical Input Requirements
500k–1M cells, viability > 85%
Workflow
CUT&RUN
Key Applications
Protein–DNA binding profiles, histone mark mapping
Typical Input Requirements
~250k cells per antibody
Workflow
ChIP-Seq
Key Applications
Transcription factor binding, histone modifications
Typical Input Requirements
≥1 ng immunoprecipitated DNA
Workflow
Methylome Profiling
Key Applications
Genome-wide methylation analysis
Typical Input Requirements
100–1000 ng high-quality DNA
Detailed input guidelines are available in the Epigenomics Whitepaper or upon request from our team.
Bioinformatics Analysis Packages
Our bioinformatics pipelines process and interpret epigenomic and epigenetic sequencing data for both bulk and single-cell projects:
- Primary Analysis: Quality control, alignment, peak calling, and methylation calling.
- Downstream Analysis: Differential peak/methylation analysis, motif enrichment, transcription factor binding prediction, and annotation to regulatory regions.
- Integrated Analysis: Cross-assay correlation of ATAC-Seq and RNA-Seq data for regulatory network inference.
- Visualization: Publication-ready figures including heatmaps, metagene profiles, methylation tracks, and peak intensity plots.
All results are delivered as high-resolution, publication-ready figures and tables suitable for manuscripts and grant submissions.
Integrating Epigenomics with Other Signios Services
Connect chromatin state insights with other layers of molecular data through our multiomic workflows:
- RNA-Seq Services – Combine transcriptomic and epigenomic data to study gene regulation.
- Single-Cell Sequencing – Pair open chromatin data with single-cell transcriptomics for deeper resolution.
- Spatial Transcriptomics – Preserve spatial context while linking gene expression with epigenomic activity.
- Proteomics Services – Integrate protein and biomarker data to complement methylome and ChIP-Seq results.
These linked services streamline study design, improve data correlation, and strengthen multiomic analysis from a single NGS provider.
Why Choose Signios Bio for Epigenomic Sequencing
Signios Bio combines advanced NGS technology with expertise in TCR and BCR repertoire analysis to provide reliable immune profiling data.
- Comprehensive Portfolio – ATAC-Seq, CUT&RUN, ChIP-Seq, and methylome profiling in one platform.
- Flexible Design – Human and model organism compatibility with low-input options.
- Expert Analysis – Advanced bioinformatics and data visualization for publication-ready results.
- Reproducible Results – Validated workflows and strict QC standards ensure consistency across replicates.
- Multiomic Expertise – Seamless integration with RNA, single-cell, and spatial datasets for deeper biological insight.
Get Started with Epigenomic Sequencing
Whether your research focuses on chromatin accessibility, histone modifications, or DNA methylation, Signios Bio provides the tools and expertise to help you uncover the epigenetic mechanisms driving your system of interest.
Our team can assist with experimental design, sample preparation, and bioinformatics support tailored to your research goals.
Frequently Asked Questions
1. What is epigenomic sequencing?
Epigenomic sequencing refers to the comprehensive analysis of chromatin states, histone modifications, and DNA methylation that regulate gene expression without altering the DNA sequence. It helps uncover how genes are turned on or off in different biological contexts.
2. What types of epigenomic sequencing services does Signios Bio offer?
Signios Bio provides a complete suite of assays including:
- ATAC-Seq (bulk and single-cell): To study chromatin accessibility and nucleosome positioning.
- CUT&RUN: For high-resolution mapping of protein–DNA interactions and histone marks.
- ChIP-Seq: For transcription factor binding and histone modification analysis.
- Methylome Profiling: For genome-wide DNA methylation analysis.
3. How much sample input is required for each assay?
Typical input requirements vary by assay:
- Bulk ATAC-Seq: ≥100k cells or 20–50 mg tissue
- Single-Cell ATAC-Seq: 500k–1M cells with >85% viability
- CUT&RUN: ~250k cells per antibody
- ChIP-Seq: ≥1 ng immunoprecipitated DNA
- Methylome Profiling: 100–1000 ng high-quality DNA
Detailed sample prep guidelines are available in our Epigenomics Whitepaper or upon request.
4. Can I combine epigenomic sequencing with RNA-Seq or other omics?
Yes. Signios Bio enables multiomic integration, allowing you to combine epigenomic data with:
- RNA-Seq for transcriptional regulation studies
- Single-cell sequencing for cell-type–specific insights
- Spatial transcriptomics to preserve tissue context
- Proteomics to link chromatin changes with protein expression
5. What kind of bioinformatics support do you provide?
We offer end-to-end bioinformatics analysis, including:
- Primary analysis: QC, alignment, peak/methylation calling
- Downstream analysis: Differential peak analysis, motif discovery, TF binding prediction
- Integrated analysis: Cross-assay correlation (e.g., ATAC-Seq + RNA-Seq)
- Visualization: Publication-ready heatmaps, metagene plots, and methylation tracks
All data are delivered as high-resolution figures and summary tables ready for publication or grant submission.
6. What makes Signios Bio’s epigenomic sequencing unique?
- Comprehensive portfolio covering all key epigenomic assays
- Validated, low-input workflows for a wide range of sample types
- Expert bioinformatics for accurate interpretation
- Reproducible, publication-ready results backed by stringent QC
- Seamless integration with RNA, single-cell, and spatial datasets
7. What turnaround time can I expect?
Turnaround time typically depends on assay complexity and sample volume. Standard bulk assays are delivered in 4–6 weeks, while multiomic or single-cell projects may require additional processing time. Expedited options are available upon request.
8. How are results delivered?
Results are provided through a secure online portal and include:
- Raw and processed data files
- Bioinformatics reports with visualizations
- Summary of key findings and analysis parameters
9. Do you assist with study design and sample preparation?
Yes. Our expert team supports researchers from the experimental design stage through sample preparation, sequencing, and data interpretation—ensuring each project aligns with your biological question and publication goals.
10. How do I get started with Signios Bio’s epigenomic sequencing?
Simply fill out the Request a Quote form or contact our team. We’ll help you choose the right assay, define input requirements, and plan your project timeline.
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