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Application notes, brochures, case studies, and whitepapers from our team. Filter by type and download the resources relevant to your research.
- Case Study
Near-chromosomal genome assembly of the bengal tiger: Advancing conservation through genomics
MedGenome (DBA Signios Bio) enabled the generation of a near-chromosomal de novo genome assembly for the Bengal tiger (Panthera tigris tigris), delivering critical insights into its genetic diversity, evolutionary adaptations, and apex predatory traits. This study, powered by MedGenome’s advanced sequencing technologies and bioinformatics expertise, highlights the potential of genomics in addressing wildlife conservation challenges and unlocking the mysteries of endangered species’ genomes.
- Case Study
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
In this study, we report a de novo near-chromosomal genome assembly of Naja naja, the Indian cobra, a highly venomous and medically important snake. With a scaffold N50 of 223.35 Mb, this is the most contiguous reptilian genome published to date.
- Brochure
High-Sensitivity, High-Throughput Protein Profiling with Olink® Reveal
Signios Bio provides Olink® Reveal proteomics—PEA-powered profiling that quantifies 1,000+ disease-relevant proteins from minimal sample input.
- Case Study
Decoding lung cancer complexity with spatial transcriptomics
Lung cancer remains the leading cause of cancer-related mortality worldwide. Genetic alterations such as KRAS mutations, EGFR mutation, overexpression, and TP53 mutations are well-known drivers of tumorigenesis in lung cancer.
- Application Note
Advancing hematologic malignancy research with integrated multiomic solutions from Signios Bio
Hematologic malignancies often exhibit intricate clonal evolution, dynamic immune microenvironments within the bone marrow and periphery, and rare cell populations critical for disease progression and relapse.
- Application Note
Advancing oncology research with comprehensive immunoprofiling solutions from Signios Bio
Understanding the complex interplay between the immune system and cancer is crucial for developing effective therapies, particularly immune checkpoint inhibitors (ICIs). However, predicting patient response and deciphering resistance mechanisms remain significant challenges.
- Application Note
Characterizing solid tumor heterogeneity with multiomic approaches from Signios Bio
Solid tumors present immense complexity, characterized by significant intra-tumoral heterogeneity (ITH) arising from genetic, epigenetic, and transcriptional diversity.
- Brochure
Spatial Transcriptomics Brochure
Spatial Transcriptomics with Signiosbio: Where gene expression meets precision
- Whitepaper
Single-Cell Sequencing Solutions Whitepaper
Multiome insights, simplified: single-cell omics solutions for diverse sample types
- Case Study
Targeted genome editing in tomato: Unraveling gene regulation in carotenoid biosynthesis
Signios Bio leveraged its expertise in plant genomics to conduct a proof of concept study on carotenoid biosynthesis in tomatoes using CRISPR/Cas9 technology, published in Plant Cell Reports
- Case Study
Genomic insights into invasive rodent populations: unlocking conservation and synthetic gene drive potential
Signios Bio supported this research by providing high-quality genomic sequencing services, enabling the generation of detailed genetic data critical for understanding population dynamics and informing innovative conservation strategies
- Brochure
Unlocking Biological Insights with Signios Bio’s Advanced Multiomics Solutions
By integrating multiple modalities with our advanced bioinformatics tools and pipelines, we provide customized solutions tailored to your unique research needs.
- Brochure
Signios Bio Bioinformatics Services
Advancing omics research with comprehensive solutions and in-depth data analysis
- Whitepaper
Signios Bio Comprehensive Variant Detection Whitepaper
Unmasking the full spectrum of human genetic variation with PacBio HiFi sequencing
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- Whitepaper
Signios Bio Spatial Transcriptomics Whitepaper
Maximize spatial transcriptomics discoveries with Signios Bio
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