US Based · NGS & Multi-Omic Core Facility
Scientist Led Multi-Omic & NGS Services
Fully customizable, end-to-end solutions executed in our SF Bay Area lab. Guided project design, advanced sample processing, and publication ready analysis tailored to your unique sample and research goals.
Our services
Explore Signios Bio's Capabilities
Compare sample specifications, library prep chemistries, sequencing options, and analysis deliverables across our workflows.
Transcriptomics
Measure gene expression across bulk, single cell, and spatial resolutions.
Genomics
Epigenetics
Chromatin accessibility and epigenetic marks controlling gene expression.
Proteomics
Profile thousands of proteins with high sensitivity, affinity-based technologies.
Immune Profiling
Bulk and single cell services for repertoire and clonal profiling.
Sequencing Only
Data delivered in as fast as 2 days, with library QC and pooling support.
Looking for multiomic solutions? Learn how we can analyze genomic, transcriptomic, immune profiling and epigenetics from a single sample.
Validated chemistries & instrument partners
The Signios advantage
Core lab infrastructure built for confidence
01
Run genomic, transcriptomic, epigenomic, and proteomic assays under a single roof — avoiding batch effects and technical drift from multi-vendor fragmentation.
02
All tissue processing, sectioning, library prep, and high-throughput sequencing performed locally at our SF Bay Area lab.
03
Workflows compatible with all sample states including FFPE, long-term stored, and fresh samples.
04
Your project is supported by scientists with advanced academic and discovery backgrounds, ensuring rigorous data review throughout.
Our NGS workflows
A seamless end-to-end experience with rigorous quality controls
Every sample entering our Foster City, CA laboratory follows a standardized, tracking-validated flow designed to preserve sample integrity and guarantee premium data delivery.
Step 1
Scientist-to-scientist consultation reviews sample states and aligns analysis goals to compatible workflows.
Step 2
Thorough QC verifies sample conditions prior to proceeding through aligned workflows.
Step 3
Library prep with liquid handling reduces manual batch variance, incorporates custom control spikes, and unique dual indexes (UDIs).
Step 4
Libraries transition to Illumina NovaSeq X Plus for short-read data depth or the PacBio Revio for flawless long-read resolution.
Step 5
Secure delivery of raw data, standard and advanced analysis with ready-to-publish reports through a secure FTP link, Google Cloud, or AWS.
Scientist-to-scientist consultation reviews sample states and aligns analysis goals to compatible workflows.
Thorough QC verifies sample conditions prior to proceeding through aligned workflows.
Library prep with liquid handling reduces manual batch variance, incorporates custom control spikes, and unique dual indexes (UDIs).
Libraries transition to Illumina NovaSeq X Plus for short-read data depth or the PacBio Revio for flawless long-read resolution.
Secure delivery of raw data, standard and advanced analysis with ready-to-publish reports through a secure FTP link, Google Cloud, or AWS.
Bioinformatics
Choose your level of analysis
Every service can pair with one of three analysis packages. Pick the level that matches how much interpretation and support you need.
Included with every tier
- FASTQ files
- Illumina Data QC report
- Alignment files (BAM)
- Processed results
- Publication ready figures
- Secure delivery (SFTP, AWS, or Google Cloud)
Standard Packages
- Standard pipelines for each platform
- QC and data filtering by our team
- Exploratory plots and summary tables
Best for teams running their own downstream analysis.
Advanced Packages
- Integrated tools across every platform
- Version-controlled processing
- Biological interpretation and reporting
Best for teams that want results interpreted for them.
Specialized Packages
- Bespoke pipelines for novel designs
- Multi-omic integration across assays
- Dedicated bioinformatician hours
Best for novel, custom, or multi-omic study designs.
Resources & Programs
Resources
Whitepapers & Technical Guides
Access our full library of whitepapers, application notes, and technical guides to support your research.
Certified Service Program
Industry-Validated Genomics
Partner with confidence through our validated service programs, delivering industry-certified genomics expertise.
Referral Program
Refer a Colleague, Earn Rewards
Share your Signios Bio experience with colleagues and earn rewards when they launch their first project.
Publications
Research Powered by Signios
Explore peer-reviewed publications and discover how researchers are leveraging our workflows for impactful science.
Frequently Asked Questions
Everything you need to plan your project
How do we initiate a sequencing project with Signios Bio?
Getting started is straightforward. Connect with our team through our portal or request forms. Our technical team maps your study goals to the best available chemistries, verifies your sample preparation conditions, and builds a transparent, customized service quote.
What sample formats and tissue types does the lab accept?
We ingest a broad range of biological inputs: purified gDNA/RNA, fresh or frozen biofluids (serum, plasma, CSF), cryopreserved cell pellets, PBMCs, and complex archived clinical FFPE blocks or slides.
What are the general sample input and quality thresholds?
Requirements scale by technology. For optimal bulk transcriptomics we recommend RIN >7, while archived FFPE sections require DV200 ≥20%. Standard genomic applications typically need 50–1000 ng of input, though low-input workflows can handle down to 10 ng for limited clinical specimens.
What bioinformatics and analytics packages are bundled?
We provide industry-standard, version-controlled workflows with every project. Standard delivery includes raw sequence parameters (FASTQ), optimized read alignments (BAM), and curated expression or variant tables (VCF, counts) backed by comprehensive QC validation reports.
What are your standard turnaround times (TAT)?
TATs are predictable and scale with sample volume and workflow. Premade library sequencing and basic bulk expression profiles deliver in as little as 1–2 weeks. Complex single-cell, spatial, or multi-modal profiles average 3–5 weeks from sample QC sign-off.
Does Signios support clinical diagnostics or regulated workflows?
Our services are engineered for pre-clinical, translational, and discovery-focused academic or biopharma research. While our protocols observe strict document controls, data tracking, and quality validation suitable to support regulatory submission packages, our lab is not a CLIA-certified or CAP-accredited diagnostic facility.
Ready to discuss your next sequencing project?
Tell us about your samples and goals. A PhD scientist replies within one business day with a tailored plan and quote.
- Guided study design & platform selection
- Competitive pricing, flexible turnaround
- Integrated bioinformatics & reporting
- Services performed in our SF Bay Area lab — Foster City, CA
Request a quote