Bioinformatics & data analysis
From raw reads to biological insight
Our automated, version-controlled pipelines transition your project from raw sequence data to publication-ready results. Industry-standard workflows tailored to your platform — with transparent QC at every step and PhD-level scientists guiding interpretation.
Analysis pipelines
Pipelines for every data type
Analysis matched to the resolution of your project — from bulk differential expression to single-cell clustering and spatial alignment.
RNA-Seq Analysis
Alignment, quantification, differential expression, pathway analysis, and gene ontology.
Single-Cell Analysis
QC, clustering, cell-type annotation, trajectory, and differential abundance.
Spatial Analysis
Spatial alignment, region annotation, and tumor-microenvironment deconvolution.
Variant Analysis
Germline & somatic calling, annotation, CNV, and structural-variant detection.
Immune & Repertoire
TCR/BCR clonotype analysis, repertoire diversity, and clonal tracking.
Multi-Omic Integration
Harmonize and jointly analyze modalities into one integrated biological story.
Analysis packages
Choose your level of analysis
Every sequencing service can pair with one of three analysis packages — from raw data to fully interpreted results.
Standard Packages
- Data QCs
- Alignments
- Standard analysis using basic tools for specific workflow
Best for teams running their own downstream analysis.
Advanced Packages
- Includes standard deliverables
- Advanced report through advanced tools
- Standard analysis related to analysis type
Best for teams that want results interpreted for them.
Specialized Packages
- Custom packages for your project goals
- Hourly analysis options
- Full-time dedicated bioinformatics models
Best for novel, custom, or multi-omic study designs.
What you receive
Transparent, publication-ready deliverables
Standard, version-controlled outputs with every project — backed by comprehensive QC validation reports.
Step 1
Raw sequence files for every sample.
Step 2
Optimized read alignments to reference species.
Step 3
Multi-stage QC, expression matrices, VCF variants, clonotypes and more.
Step 4
Custom analysis and support all the way through publication.
Raw sequence files for every sample.
Optimized read alignments
to reference species.
Multi-stage QC, expression matrices, VCF variants, clonotypes and more.
Custom analysis and support all the way through publication
Visualizations we deliver
Scoring Heat Map
Delta Distribution
Clonotype Expansion
Cell Type Annotation
Dimensionality Reduction (UMAP / t-SNE) Cluster Plots
Alignment stats
PCA Plot
Correlation Plot
Heatmap
Gene Networks
AI-assisted analysis
Explore your results interactively
Query your data and generate figures with our AI analysis platform — ask questions of your results and iterate without waiting.
Resources & Insights
Tech Sheet & Brochure
RNA-Seq Bioinformatics Overview
Download our comprehensive bioinformatics service guide detailing our validated gold-standard pipelines, workflow specificities, and custom visualization deliverables.
Analysis Overview
Signios Bio bioinformatics services
End-to-end pipelines transforming raw sequencing data into actionable genomic insights, including QC, FASTQ/BAM/VCF generation, germline and somatic variant annotation, CNVs, SVs, joint genotyping, and gVCF outputs, with flexible analysis packages.
Whitepaper
Signios Bio Comprehensive Variant Detection
Learn about our computational precision pipelines, gold-standard GATK workflows, and how we transition raw reads into publication-ready, annotated biological insights.
Frequently Asked Questions
Bioinformatics, answered
Is analysis bundled with sequencing?
Every project includes standard, version-controlled workflows and QC reports. You can add Advanced or Specialized packages for deeper interpretation.
Can you analyze data sequenced elsewhere?
Yes. We offer analysis-only engagements — send us your FASTQ/BAM files and we’ll run the appropriate pipeline and interpretation.
How is multi-omic data integrated?
We harmonize modalities onto a shared framework and run joint analyses that correlate signals across layers — delivering one integrated report.
How are results delivered?
Securely via SFTP or cloud transfer — FASTQ, BAM, results tables, and QC reports, with figures ready for publication.
Explore Related Sequencing Solutions
High-resolution transcriptomics to resolve individual cellular heterogeneity.
High-sensitivity, scalable gene expression profiling and transcriptome mapping.
Resolving complex structural variations and full-length RNA isoforms.
High-plex protein profiling for functional multi-omic integration.
Need help turning data into insight?
Tell us about your data and goals. A PhD scientist replies within one business day with the right analysis package and a tailored plan and quote.
- Automated, version-controlled pipelines
- Transparent QC at every step
- PhD-level scientists guiding interpretation
- Publication-ready results & reporting
Request a quote