Documents
Decoding lung cancer complexity with spatial transcriptomics
Lung cancer remains the leading cause of cancer-related mortality worldwide. Genetic alterations such as KRAS mutations, EGFR mutation, overexpression, and TP53 mutations are well-known drivers of tumorigenesis in lung cancer.
Advancing hematologic malignancy research with integrated multiomic solutions from Signios Bio
Hematologic malignancies often exhibit intricate clonal evolution, dynamic immune microenvironments within the bone marrow and periphery, and rare cell populations critical for disease progression and relapse.
Advancing oncology research with comprehensive immunoprofiling solutions from Signios Bio
Understanding the complex interplay between the immune system and cancer is crucial for developing effective therapies, particularly immune checkpoint inhibitors (ICIs). However, predicting patient response and deciphering resistance mechanisms remain significant challenges.
Characterizing solid tumor heterogeneity with multiomic approaches from Signios Bio
Solid tumors present immense complexity, characterized by significant intra-tumoral heterogeneity (ITH) arising from genetic, epigenetic, and transcriptional diversity.
Spatial Transcriptomics Brochure
Spatial Transcriptomics with Signiosbio: Where gene expression meets precision
Single-Cell Sequencing Solutions Whitepaper
Multiome insights, simplified: single-cell omics solutions for diverse sample types
Targeted genome editing in tomato: Unraveling gene regulation in carotenoid biosynthesis
Signios Bio leveraged its expertise in plant genomics to conduct a proof of concept study on carotenoid biosynthesis in tomatoes using CRISPR/Cas9 technology, published in Plant Cell Reports
Genomic insights into invasive rodent populations: unlocking conservation and synthetic gene drive potential
Signios Bio supported this research by providing high-quality genomic sequencing services, enabling the generation of detailed genetic data critical for understanding population dynamics and informing innovative conservation strategies
Unlocking Biological Insights with Signios Bio’s Advanced Multiomics Solutions
By integrating multiple modalities with our advanced bioinformatics tools and pipelines, we provide customized solutions tailored to your unique research needs.
Signios Bio Bioinformatics Services
Advancing omics research with comprehensive solutions and in-depth data analysis
Signios Bio Comprehensive Variant Detection Whitepaper
Unmasking the full spectrum of human genetic variation with PacBio HiFi sequencing
Signios Bio Spatial Transcriptomics Whitepaper
Maximize spatial transcriptomics discoveries with Signios Bio
Signios Bio Full-Length RNA Sequencing Whitepaper
Unravelling transcriptome complexity: full-length RNA sequencing with PacBio
Signios Bio Advanced Single-Cell Analysis Whitepaper
Signios Bio’s advanced bioinformatics solutions to analyze single-cell sequencing
Signios Bio Genome Assembly and Annotation Whitepaper
Unlocking genomic potential: de novo genome assembly and annotation with
Signios Bio HiTMab Antibody Discovery Whitepaper
HiTMab – Monoclonal antibody discovery solutions
Signios Bio TSO 500 Whitepaper
Comprehensive genomic profiling of clinically relevant cancer genes with Illumina’s TruSight Oncology 500 (TSO 500) NGS assay
Signios Bio Epigenetic Sequencing Whitepaper
Epigenetic insights: Signios Bio’s comprehensive approach to single-cell ATAC-seq, CUT&RUN and multiome analysis
Signios Bio B Cell Receptor Profiling Whitepaper
Human B cell receptor profiling service at Signios Bio
Signios Bio Whole Exome Sequencing Brochure
Signios Bio’s Advanced Whole Exome Sequencing Solutions
Signios Bio T Cell Receptor Repertoire Sequencing Whitepaper
T cell receptor (TCR) repertoire sequencing
Signios Bio PacBio Sequencing Brochure
Long read sequencing with Signios Bio: Never miss a base
Signios Bio Plant and Animal Sciences Brochure
Accelerating plant and animal research with cutting-edge genomic solutions
Signios Bio OncoPeptTUME Whitepaper
OncoPeptTUMETM — A novel in-silico approach to model the tumor microenviroment and predict treatment efficacy and long-term survival benefits for immunotherapy applications
Signios Bio Hematology Brochure
Empowering hematology discoveries with precision and depth
Signios Bio Services Brochure
Precision NGS data, fast turnaround, insightful bioinformatics: Complete solutions for every sample type