US Based · Genomics Sequencing Services
Whole Genome, Exome, Long-Read & Targeted Panel Services
Comprehensive whole-genome mapping, deep exomic coverage, long-read structural resolution, and hyper-targeted somatic cancer panels services. Industry-leading platforms and chemistries from Illumina, PacBio and Twist Bioscience for all sample types.
Genomics Services
Comprehensive variant, structural, and translational insights
Whole Genome Sequencing Services
Complete, unbiased gene and non-coding profiling using the newest Illumina and Twist chemistries. Optimized for germline, population cohorts, tumors and complex somatic variant identification.
Whole Exome Sequencing Services
Deep, cost-effective coverage of the protein-coding exome. Precision target-enrichment to identify rare variants, disease-linked mutations,
and neoantigens.
PacBio Long-Read Genomics Services
Resolve complex structural variants, repetitive genomic regions, pseudogenes, and long-range haplotype phasing with single-molecule HiFi sequencing.
Oncology Targeted Panel Services
High-depth profiling of actionable cancer genes. Detect ultra-low-frequency somatic mutations, tumor mutational burden (TMB),
and microsatellite instability (MSI).
The Signios Advantage
Superior Workflow Performance & Technical Excellence
From sample extraction through final multi-omic variant integration, our optimized protocols maximize genomic recovery, sequencing depth, and variant calling accuracy across every project.
End-to-End Solutions
Extraction, library preparation, sequencing and bioinformatics—all managed within a single laboratory.
Low-Input Sensitivity
Validated protocols for precious samples down to picogram levels, as well as archived tissues and FFPE.
Multi-Platform Sequencing
Access comprehensive services featuring Illumina short-read, PacBio long-read, and advanced enrichment methods custom-tailored to your study goals.
US-Based Services
All genomics services are performed in-house at our Foster City, CA facility. No outsourcing or international shipping.
Expert Support
Every project is overseen by PhD-level scientists providing guidance on study design, cohort power, platform selection, QC consultation, and downstream variant interpretation.
Fast Turnaround Times
Optimized protocols utilizing state-of-the-art liquid handlers for efficient sample processing and rapid data delivery.
The Signios Partnership
Laboratory Workflow & Quality Assurance
A transparent, five-step workflow designed to preserve sample integrity and ensure high-confidence genomic data generation.
Step 1
Our scientists provide dedicated guidance to align our technical workflows (WGS, WES, long-read, or targeted panels) with your coverage depth and research objectives.
Step 2
Register samples via our streamlined customer portal. Schedule a local Bay Area pick-up or ship directly when ready.
Step 3
We provide formal Qubit, TapeStation, or Agilent Fragment Analyzer reports for your review, ensuring full transparency and customer sign-off before library construction.
Step 4
Libraries are QC’d and pooled to ensure high-fidelity, balanced data outputs from our advanced Illumina and PacBio sequencing platforms.
Step 5
Secure delivery of FASTQ/VCF files and QC reports via SFTP or direct cloud transfer. Bioinformatics services are available for publication-ready genomic interpretation.
Our scientists provide dedicated guidance to align our technical workflows (WGS, WES, long-read, or targeted panels) with your coverage depth and research objectives.
Register samples via our streamlined customer portal. Schedule a local Bay Area pick-up or ship directly when ready.
We provide formal Qubit, TapeStation, or Agilent Fragment Analyzer reports for your review, ensuring full transparency and customer sign-off before library construction.
Libraries are QC’d and pooled to ensure high-fidelity, balanced data outputs from our advanced Illumina and PacBio sequencing platforms.
Secure delivery of FASTQ/VCF files and QC reports via SFTP or direct cloud transfer. Bioinformatics services are available for publication-ready genomic interpretation.
Beyond the FASTQ
Comprehensive Bioinformatics for Our Genomics Services
Our automated bioinformatics pipelines transition your project from raw sequencing data to biological insight. Industry-standard workflows tailored to the resolution of your project—ranging from germline variant calling to complex somatic tumor annotations and structural variant filtering.
Deliverables Include
- FASTQ files
- Illumina Data QC report
- Alignment files (BAM)
- Processed results
- Publication-ready figures
- Secure delivery (SFTP, AWS, or Google Cloud)
SNV & Indel Distribution
Somatic Variant Analysis
CNV & Structural Events
Publication-Ready Figures
Applications of Genomics Sequencing
Our high-level genomics services support a broad range of multi-disciplinary applications, including:
Somatic & Germline Variant Mapping
Identifying single nucleotide variants (SNVs) and small indels to uncover underlying hereditary patterns or disease drivers.
Structural Variation & Phasing
Uncovering large inversions, duplications, translocations, and defining haplotype context using PacBio long-read platforms.
Oncology & Immunotherapy Biomarkers
Profiling tumor genetics to track subclonal heterogeneity, mutational burdens, and direct personalized neoantigen exploration.
Rare & Mendelian Disease Identification
Pinpointing causative point or splicing variations across protein-coding domains via targeted exome enrichment.
Therapeutic Mechanism & Pharmacogenomics
Evaluating genetic variations that alter drug metabolism, systemic toxicity, and patient-specific therapeutic responses.
Resources & Insights
SERVICE OVERVIEW | TECH SHEET
Whole Exome Sequencing Services
Learn about our end-to-end WGS and WES workflows, optimized for standard inputs, population scales, and challenging clinical FFPE tissues to maximize variant discovery.
SERVICE OVERVIEW | TECH SHEET
PacBio Long-Read Genomics Services
Explore our high-fidelity (HiFi) long-read workflows. Discover how we map large structural variations, resolve dark regions, and phase complete genomic haplotypes.
SERVICE OVERVIEW | TECH SHEET
Oncology Targeted Panel Services
Download the technical overview of our oncology panels to see how we track low-frequency mutations, TMB, and MSI across solid tumors and liquid biopsy applications.
Frequently Asked Questions
Everything you need to plan your project
How do I choose between WGS, WES, and Targeted Panels?
WGS offers a complete, unbiased view of coding and non-coding regions. WES focuses strictly on protein-coding regions for deep, cost-effective screening of functional mutations. Targeted Panels provide extreme depth of coverage over select oncogenes/biomarkers, making them ideal for tracking rare somatic sub-clones.
What sample types are compatible across your platforms?
Our services are validated for an extensive range of genomic inputs: whole blood, fresh-frozen tissue, cultured mammalian and microbial cells, saliva, and degraded clinical FFPE blocks.
What is the typical turnaround time (TAT)?
Our standard turnaround time is 3–4 weeks from sample QC approval. We offer expedited services for select whole genome and target-enriched workflows down to 10–12 business days.
What are the sample DNA requirements?
Requirements vary by assay:
- WGS / WES: Prefer >10–50 ng purified DNA, but low-input workflows can adjust down to picogram thresholds.
- PacBio Long-Read: Requires high-molecular-weight (HMW) DNA with minimal fragmentation (DIN >7 preferred).
- FFPE / Targeted Panels: Extracted DNA is evaluated on fragment size; low-input repair steps are applied as needed.
What sequencing platforms are utilized in-house?
We utilize the Illumina NovaSeq X Plus platform for high-throughput short-read processing (PE150), alongside advanced PacBio Revio instruments for high-fidelity (HiFi) long-read sequencing.
What type of quality control (QC) is provided?
All incoming DNA samples undergo rigorous validation using Qubit fluorometric quantification and TapeStation or Fragment Analyzer size architectures. Full transparency and formal reports are shared before proceeding with any run.
Explore Related Sequencing Solutions
High-resolution transcriptomics to resolve individual cellular heterogeneity.
Resolving complex structural variations and full-length RNA isoforms.
High-plex protein profiling for functional multi-omic integration.
Start your genomics project
Tell us about your samples and goals. A PhD scientist replies within one business day with the right workflow and a tailored quote.
- US-based, in-house at Foster City, CA
- Illumina NovaSeq X Plus & PacBio Revio
- WGS, WES, long-read & targeted panels
Request a quote